Peptides researched primarily for therapeutic or restorative purposes and generally compatible with natural designation.
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- Afamelanotide — Raises skin melanin by activating MC1 receptors. Approved to prevent phototoxic pain in erythropoietic protoporphyria, a rare genetic light sensitivity. Given as a subcutaneous implant.
- Bremelanotide — FDA-approved (as Vyleesi) for low libido in premenopausal women. Activates central melanocortin receptors to drive arousal. Shows preclinical promise for erectile dysfunction. Given by subcutaneous injection.
- Glutathione — The body's master intracellular antioxidant. Scavenges free radicals and supports liver phase-II detoxification. Regenerates vitamins C and E. Used for liver health, skin brightening, and anti-aging.
- NAD+ — Boosts cellular energy production and DNA repair. Activates longevity enzymes. Early studies on metabolism and mitochondrial function show mixed results. Cellular benefits proven, human longevity unproven.
- Ozempic — Reduces appetite and slows digestion for 15-21% weight loss. Improves blood sugar control. Lowers heart attack and stroke risk by 20%.
- Tirzepatide — Dual GIP/GLP-1 agonist for weight loss of up to about 21% and better blood sugar control. First drug approved for obstructive sleep apnea. GI side effects common.
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Bioactive molecules