Delta-sleep-inducing peptide

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Medical disclaimer. This article is for informational purposes only and does not constitute medical advice. Consult a qualified clinician before considering any compound discussed below. See Retapedia : Medical disclaimer.

Summary

What it does
Delta-sleep-inducing peptide is used for deeper sleep. The link to human sleep is weak, so it may do little.
How it works
A short natural brain peptide, given by injection. Its name comes from the deep-sleep brain waves it produced in laboratory work. How it acts in the human brain is still poorly understood.
WADA status
Prohibited by the World Anti-Doping Agency (WADA). Drug-tested athletes cannot use it.

Delta-sleep-inducing peptide is a performance-enhancing peptide studied for its effects on sleep, injectable, subcutaneous. Delta-sleep-inducing peptide (DSIP) is a neuropeptide tied to animal EEG sleep activity; its human sleep role is weak. Shows preclinical antiepileptic activity.

Delta-sleep-inducing peptide (DSIP) is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities. As an unapproved research peptide with no regulatory approval for human therapeutic use, it is prohibited by WADA at all times under category S0 (non-approved substances).

Natty status
Delta-sleep-inducing peptide is classified as not natty. It is prohibited by WADA and most natural bodybuilding federations. Use places the athlete in the enhanced category. See § Natty status.
Contents [hide]
  1. 1 Mechanism of action
  2. 2 Reported effects
  3. 3 Natty status
  4. 4 Research
  5. 5 Related compounds
  6. 6 References
  7. 7 External links

Mechanism of action

A neuropeptide named for inducing delta EEG sleep activity in animals, though its own link to human sleep is weak and poorly characterized. Shows preclinical antiepileptic activity.

Reported effects

Effects reported in the literature and from preclinical models include:

  • DSIP and its analogues are proposed to stabilize brain excitability and act as potent antiepileptics in metaphit-induced generalized audiogenic convulsive activity. [1] Preclinical
  • Certain artificial DSIP structural analogues, but not DSIP itself, significantly promoted slow-wave sleep in rabbits and rats. [2] Preclinical
  • A naturally occurring dermorphin-decapeptide structurally similar to DSIP promoted slow-wave sleep in rabbits, while its optical isomer suppressed sleep. [2] Preclinical
  • In vitro biochemical and physiological studies show DSIP has a wide spectrum of biological activity. [2] Preclinical
  • DSIP-like immunoreactivity is distributed in the neurosecretory hypothalamic nuclei of various vertebrate species, in regions not particularly relevant to sleep regulation. [2] Preclinical

Evidence grades: FDA approvedApproved (non-US)Phase IIIPhase IIPhase IPreclinicalAnecdotal

Natty status

See also: Peptide § Natty status

Delta-sleep-inducing peptide is classified as not natty. It appears on the WADA prohibited list and is banned by major natural bodybuilding federations.[3] Use of this compound places the athlete in the enhanced category rather than the natural category in competitive contexts.

Research

No registered human trials on ClinicalTrials.gov, in any status
View on ClinicalTrials.gov · fetched Sep 4, 2026

The peptide has been the subject of 3 studies and reference works collected on this site. Additional bibliography is in § External links below.

Other peptides in this catalogue with overlapping mechanisms or status:

Epithalon Not natty
Marketed as an anti-aging peptide. In preclinical studies it boosts telomerase activity, supports the body's own melatonin production, and shows antioxidant effects. Human evidence is minimal.
IGF-1 LR3 Not natty
Long-acting IGF-1 analog studied preclinically for muscle growth and tissue repair. No peer-reviewed human evidence of benefit. Risks include hypoglycemia, joint pain, unproven cancer concerns.
Ipamorelin Not natty
Selectively triggers growth hormone release without raising cortisol or prolactin. Human efficacy unproven: a Phase 2 trial failed and body-composition benefits remain preclinical. Subcutaneous injection.
Melanotan II Not natty
Stimulates melanin production to darken skin and facilitate tanning. May also increase sexual arousal and reduce appetite. Unapproved for human use; linked to nausea and mole changes.

References

  1. ^ [Endogenous anticonvulsants: neuropeptide Y and delta sleep inducing peptide]. Review
  2. a b c d Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Review
  3. a b World Anti-Doping Agency. (2026). Prohibited List 2026.

External links

Categories: Peptides | Performance-enhancing substances | Sleep | Injectable | Subcutaneous

This page was last updated on September 4, 2026, at 13:13 (UTC).

Research last reviewed on September 4, 2026.

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