Selank

From Retapedia, the free peptide encyclopedia
Medical disclaimer. This article is for informational purposes only and does not constitute medical advice. Consult a qualified clinician before considering any compound discussed below. See Retapedia : Medical disclaimer.

Summary

What it does
Selank is used to ease anxiety and to support clearer thinking, and reported to do so without drowsiness or dependence.
How it works
A laboratory-made version of tuftsin, a natural human peptide, usually given as a nasal spray and sometimes as an injection under the skin. It is reported to act on the calming GABA system and on mood chemicals in the brain. Russia registers it as a medicine; the United States and Europe do not.
WADA status
Prohibited by the World Anti-Doping Agency (WADA). Drug-tested athletes cannot use it.

Selank is a peptide studied for its effects on cognition, mood, and inflammation. Selank is a synthetic tuftsin analogue used in Russia as an anxiolytic and nootropic medicine; it holds no FDA or EMA approval.

Selank is a nootropic anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It is a synthetic analogue of the human tuftsin.

Natty status
Selank is classified as not natty. It is prohibited by WADA and most natural bodybuilding federations. Use places the athlete in the enhanced category. See § Natty status.
Contents [hide]
  1. 1 Overview
  2. 2 Mechanism of action
  3. 3 Reported effects
  4. 4 Dosage and administration
  5. 5 Natty status
  6. 6 Research
  7. 7 Related compounds
  8. 8 Frequently asked questions
  9. 9 References
  10. 10 External links

Overview

The Pro-Gly-Pro tail is the same stabilising extension used in Semax, and Selank is reported to act on GABAergic and monoamine signalling and on enkephalin metabolism rather than by binding a benzodiazepine site, which is the basis for its claimed anxiolytic effect without sedation or dependence.

It is registered as a medicine in Russia but holds no FDA or EMA approval.

Selank is not named individually on the World Anti-Doping Agency (WADA) Prohibited List, and no section of that list clearly reaches a tuftsin analogue, so its status is genuinely unsettled; it is treated here as prohibited on the conservative assumption that a compound registered only in Russia may be caught by the non-approved-substances category.

Mechanism of action

Synthetic tuftsin analogue used as an anxiolytic nootropic. Reported to act on GABA and monoamine signalling without sedation or dependence. Registered as a medicine in Russia only.

Reported effects

Effects reported in the literature and from preclinical models include:

  • Selank is described as a neuroactive peptide that enhances brain-derived neurotrophic factor and HGF/c-Met signalling pathways involved in neuroplasticity. [1] Preclinical

Evidence grades: FDA approvedApproved (non-US)Phase IIIPhase IIPhase IPreclinicalAnecdotal

Dosage and administration

⚠
Dosage information is included for encyclopedic purposes only. Retapedia does not provide medical advice. See Retapedia : Medical disclaimer.

No FDA

  • or EMA-approved dose; Russian clinical protocols are the only formal dosing reference

General

  • Commonly cited at 250-500mcg daily intranasally, using a 0.15% solution
  • Russian protocols typically run short courses of 10-14 days rather than continuous use
  • Split across both nostrils, often divided into two or three doses across the day

Doses outside the Russian indications are self

  • reported and not established by controlled trials

Natty status

See also: Peptide § Natty status

Selank is classified as not natty. It appears on the WADA prohibited list and is banned by major natural bodybuilding federations.[2] Use of this compound places the athlete in the enhanced category rather than the natural category in competitive contexts.

Research

0 active clinical trials on record . 10 registered in total , of which 8 completed — highest phase ever: Phase 3
View on ClinicalTrials.gov · fetched Oct 5, 2026

The peptide has been the subject of 2 studies and reference works collected on this site. Additional bibliography is in § External links below.

Other peptides in this catalogue with overlapping mechanisms or status:

Semax Not natty
Synthetic ACTH(4-10) analogue used in Russia as a nootropic and neuroprotectant. Reported to raise BDNF without corticosteroid effects. Evidence is mostly preclinical; no FDA or EMA approval.
TB-500 Not natty
Speeds wound healing, muscle and tendon recovery. Reduces inflammation, improves joint mobility, minimizes scar tissue formation.
BPC-157 Not natty
Speeds healing of tendons, ligaments, muscles, and gut lining. Promotes new blood vessel growth and reduces inflammation. Evidence is almost entirely from animal studies.
Delta-sleep-inducing peptide Not natty
A neuropeptide named for inducing delta EEG sleep activity in animals, though its own link to human sleep is weak and poorly characterized. Shows preclinical antiepileptic activity.

Frequently asked questions

What is Selank?

Selank is a synthetic tuftsin analogue used in Russia as an anxiolytic and nootropic medicine; it holds no FDA or EMA approval.

What is Selank used for?

Selank is used to ease anxiety and to support clearer thinking, and reported to do so without drowsiness or dependence.

How does Selank work?

A laboratory-made version of tuftsin, a natural human peptide, usually given as a nasal spray and sometimes as an injection under the skin. It is reported to act on the calming GABA system and on mood chemicals in the brain. Russia registers it as a medicine; the United States and Europe do not.

Is Selank natty?

No. Selank is classified as not natty. It is prohibited by WADA and banned by most natural bodybuilding federations. Use places an athlete in the enhanced category.

Is Selank banned by WADA?

Yes. Selank is prohibited by the World Anti-Doping Agency (WADA), so drug-tested athletes cannot use it. Check the current WADA Prohibited List before competing.

How is Selank administered?

Selank is typically administered via: intranasal, subcutaneous injection. Dosage and administration protocols vary; see the Dosage section for details.

References

  1. ^ Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. Recent review
  2. a b World Anti-Doping Agency. (2026). Prohibited List 2026.

External links

Categories: Peptides | Performance-enhancing substances | Cognition | Mood | Anti-inflammatory | Injectable

This page was last updated on October 5, 2026, at 07:30 (UTC).

Research last reviewed on October 5, 2026.

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